Data Availability StatementAll data generated or analysed in this scholarly research are contained in the distribution. diabetic model Lanabecestat in Wistar rats induced with streptozotocin 60?mg/kg bodyweight by solitary intraperitoneal injection. Rats had been euthanized after one month (DM1 group, The entire contents from the supplement are available online at https://bmcproc.biomedcentral.com/articles/supplements/volume-13-supplement-11 . Abbreviation Lanabecestat ACAbdominal circumferrenceAGEAdvance-glycation end productsBMIBody mass indexCD68Cluster of differentiation 68DMDiabetes mellitusECEndothelial cellEDTAEthylenediaminetetraacetic acideNOSEndothelial nitrite oxide synthaseFBGFasting blood glucoseFFAFree fatty acidGAGGlycosaminoglycanGlcNAcN-AcetylglucosamineGM-CSFGranulocyte-macrophage colony-stimulating factorsHbA1cGlycated haemoglobin (A1c)HEKHuman embryonic kidneyHSHeparan sulphateICAM-1Intercellular adhesion molecule-1IL6Interleukin-6iNOSInducible nitrite oxide synthaseIRIIschemic reperfussion injuryLDLLow density lipoproteinMCP-1Monocyte chemoattractant protein-1MIPMacrophage inflammatory proteinsNF BNuclear factor kappa betaPAI-1Plasminogen activated inhibitor-1qRT-PCRQuantitative real time polymerase chain reactionRASRenin-angiotensin systemRNARibonucleic acidROSReactive oxygen speciesRT-PCRReverse transcriptase polymerase chain reactionSASPSenescence-associated secretory phenotypeSDS-PAGESodium duodecyl sulphate-Poly acrylamide gel electrophoresisTBSTTris buffer saline with Tween20 Authors contribution NA carried out design of the study and drafted the manuscript. NA, WA, MR and DC carried out the population study. WA and DC performed RT-PCR analysis and immunohistochemistry analysis. All the authors approve the final HDAC6 manuscript. Funding This research was funded by Nutrifood Research Center (NRC) Grant 2017C2018. Publication was funded by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Indonesia. Availability of data and materials All data generated or analysed during this study are included in the submission. The raw data are available from the corresponding author on reasonable request. Ethics approval and consent to participate This study has been approved by the Ethical Committee of the Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada/Dr. Sardjito Hospital with ethical expediency number KE/FK/0490/EC/2018. All of the participants have been Lanabecestat agreed on joining the study. Informed consent has been signed by the participants before joining the study. Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Footnotes Publishers Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations..