The class I p21-activated kinases (Pak1-3) regulate many essential biological processes
The class I p21-activated kinases (Pak1-3) regulate many essential biological processes including cytoskeletal rearrangement cell cycle progression apoptosis and cellular transformation. A characteristic that distinguishes the atypical MAPKs from the classical MAPK isoforms is the lack of the characteristic “T(16). However a cell fractionation approach to identify the kinases responsible for Erk3 Ser189 phosphorylation suggested … [Read more…]