Background: Cotton industry workers are exposed to various hazards in the different departments of textile factories. both the groups. Statistical Analysis Used: Student’s < 0.0001) decrease in forced expiratory volume in 1 s (FEV1), ratio of FEV1 and forced vital capacity (FVC) and peak expiratory flow rate, and no significant difference of FVC TC-A-2317 HCl supplier between groups. There was an association of duration of exposure and symptoms with spirometric abnormality. Conclusion: Cotton mill workers showed a significant decrease in spirometric parameters and increase in respiratory symptoms. As the duration of exposure and symptoms increased, spirometric abnormality increased. < 0.0001) was found between groups. Cotton mill workers were divided according to the presence and absence of symptoms as asymptomatic workers and symptomatic workers. Out of 100 cotton mill workers, 15 subjects were asymptomatic, and 85 subjects were symptomatic. Normal spirometry was present in 11 asymptomatic workers and 19 symptomatic workers. Abnormal spirometry was present in four asymptomatic workers and 66 symptomatic workers. Table 6 and Figure 3 show association between spirometry result according to the presence or absence of symptoms in cotton mill workers. Chi-square test was statistically significant (< 0.0001), and it shows that spirometric abnormality was more prevalent in symptomatic workers. According to the duration of exposure, cotton mill workers were divided as 5 years of exposure and >5 years of exposure. Table 7 and Figure 4 show association between spirometry results according to the duration of exposure. Chi-square test shows statistically significant association between spirometric abnormality and duration of exposure (< 0.0001). It shows that as the duration of exposure increased, spirometric abnormality increased. Table 8 shows correlation between duration of exposure and age calculated using spearman correlation test. There was a positive correlation between age and duration of exposure. Table 1 Baseline characteristics of the subjects Table 2 Spirometry parameters of control group Table 3 Spirometry parameters of cotton mill workers Table 4 Comparison of Spirometric parameters between cotton mill workers and control subjects Figure 1 Comparison of observed mean values of forced TC-A-2317 HCl supplier vital capacity, forced expiratory volume in 1 s and peak expiratory flow rate Figure 2 Comparison of observed mean values of forced expiratory volume in 1 s/forced vital capacity Table 5 Comparison of respiratory symptoms between groups Table 6 Oxytocin Acetate Chi-square test to find association of spirometry according to presence or absence of symptoms Figure 3 Spirometry results in asymptomatic and symptomatic workers Table 7 Chi-square test to find association between spirometry according to duration of exposure Figure 4 Spirometry results according to duration of exposure Table 8 Correlation between duration of exposure and age DISCUSSION The aim of the present study was to assess the effect of cotton dust exposure on pulmonary function and respiratory symptoms in cotton mill workers. The result of the present study shows that the TC-A-2317 HCl supplier complaints of respiratory symptoms such as breathlessness, cough, and chest tightness were more in cotton mill workers compared to control subjects. The findings of the study show that spirometric parameters such as FEV1, FEV1/FVC, and PEFR were significantly decreased in cotton mill workers compared to control subjects. There was no significant difference of FVC between groups. TC-A-2317 HCl supplier This suggests the obstructive type of lung function abnormality in cotton mill workers. Similar results have been observed in other study. The findings of the present study were similar to the study of Mansouri et al. They found that long-term exposure to cotton dust is associated with obstructive disease that increases with the duration of exposure. They also performed chest radiography and high-resolution computed tomography scan and found bronchial wall thickening and air trapping, respectively. Nagoda et al. found that complaints of respiratory symptoms such as cough, phlegm production, rhinitis, wheezing, chest pain, and.