Since its first description in by Drs Nusslein-Volhard and Wieschaus in
Since its first description in by Drs Nusslein-Volhard and Wieschaus in 1980, hedgehog (Hh) signaling continues to be implicated in regulation of cell differentiation, proliferation, tissue polarity, stem cell maintenance, and carcinogenesis. mammalian cells PHCCC possess many novel cytoplasmic regulators of Hh signaling, including Rab2376 and tectonic.77 Rab23 and tectonic are adverse regulators downstream of … [Read more…]