In tauopathies, a neural microtubule-associated protein tau (MAPT) is abnormally aggregated
In tauopathies, a neural microtubule-associated protein tau (MAPT) is abnormally aggregated and forms neurofibrillary tangle. and normally binds 19685-10-0 IC50 to microtubule and takes on a fundamental function in stabilization of microtubules [3, 4]. The microtubule (MT)-binding capacity for tau is controlled by its phosphorylation [5]. In tauopathies and Advertisement, hyperphosphorylated tau dissociates from microtubules, … [Read more…]