History and Purpose Monoglyceride lipase (MGL) degrades 2-arachidonoyl glycerol (2-AG), an
History and Purpose Monoglyceride lipase (MGL) degrades 2-arachidonoyl glycerol (2-AG), an endogenous agonist of cannabinoid receptors (CB1/2). propulsion and had been hypersensitive to receptor agonist-mediated inhibition of colonic motility. This phenotype was reproduced by chronic pharmacological inhibition of MGL. Summary and Implications Continuously elevated 2-AG amounts induce serious desensitization of intestinal CB1 receptors and improved … [Read more…]