We28 and others30 previously showed that macrophage differentiation required a moderate and transient activation of NF-B transcription factor
We28 and others30 previously showed that macrophage differentiation required a moderate and transient activation of NF-B transcription factor. (MCP-1) in response to CD40 ligand. We conclude that TRAF2 expression and subsequent degradation are required for the differentiation of monocytes into fully functional macrophages. Introduction Tumor necrosis factor receptor (TNFR)Cassociated factors (TRAFs) form an evolutionarily conserved … [Read more…]