Supplementary Materials Appendix EMMM-9-1398-s001
Supplementary Materials Appendix EMMM-9-1398-s001. acetaldehyde, to FANCD2\deficient cells similarly. We demonstrate that inactivation of HR factors BRCA1, BRCA2, or RAD51 hypersensitizes cells to acetaldehyde treatment, in spite of the FA pathway being functional. Aldehyde dehydrogenases (ALDHs) play key functions in endogenous acetaldehyde detoxification, and their chemical inhibition leads to cellular acetaldehyde accumulation. We find that … [Read more…]