Objective Individual Immunodeficiency Pathogen (HIV) infection and antiretroviral treatment are connected

Objective Individual Immunodeficiency Pathogen (HIV) infection and antiretroviral treatment are connected with metabolic and cardiovascular complications that resemble the metabolic symptoms (met-syndrome) and potentially SB590885 SB590885 raise the threat of diabetes and coronary disease within this population. of met-syndrome motivated using the NCEP-ATPIII requirements. Fisher’s exact check was utilized to identify gender distinctions and logistic regression to examine the result old gender smoking many years of HIV infections antiretroviral therapy and Hepatitis C co-infection. Outcomes The prevalence of met-syndrome inside our research group (35.4%) was greater than previously reported in america although not greater than in the overall inhabitants in PR. Females acquired an increased prevalence of met-syndrome (44.2%) than men (30.5%); described by high BMI and waist circumference mostly. Gender and Age group were from the existence of met-syndrome. Conclusion Understanding cultural and gender distinctions in the prevalence of metabolic risk elements is vital for the execution of particular targeted interventions to avoid following vascular morbidity and mortality within this inhabitants. Keywords: HIV metabolic symptoms Hispanics Launch The availability of highly active antiretroviral therapy (HAART) has significantly improved life expectancy for people living with Human Immunodeficiency Virus (HIV) infection. This clinical advance in therapy is associated with an increased risk of metabolic and cardiovascular complications such as visceral fat accumulation dyslipidemia (i.e. high triglycerides low HDL) insulin resistance and elevated blood pressure1 2 all important components of the metabolic syndrome (met-syndrome). However SB590885 the potential synergy of metabolic complications in HIV infection therapy and race/ethnicity has not been evaluated. Hispanics are disproportionately affected with diseases linked to the met-syndrome such as overweight/obesity diabetes and hypertension3 4 and the age-adjusted SB590885 prevalence of met-syndrome among Hispanics in the United States (US) (40.6%) is higher compared with non-Hispanic Blacks (38.8%) and Whites (31.5%).5 Moreover the age-adjusted prevalence of met-syndrome among Hispanics in Puerto Rico (PR) (38.1%)6 is similar to non-Hispanic Blacks in the US7 and higher than Hispanics in different Latin American countries.8 The prevalence of met-syndrome and cardio-metabolic risk factors among Hispanics living with HIV in PR is unknown and MAP2K2 little is known about the prevalence of these complications among Hispanics living with HIV in general. Therefore the purpose of this study was to determine the prevalence of met-syndrome and the individual cardio-metabolic risk factors in Hispanic adults living with HIV in PR. METHODS Study Design This cross-sectional study included all adult patients attending two HIV clinics and one HIV community-based alternative medicine program in San Juan PR between 2003 and 2007. These sites provide health care services to approximately 20% of the HIV/AIDS population living in PR9. Clinical records were reviewed and data extraction without personal identifiers completed by authorized personnel at each site. The consistency of data extraction and entry was checked by randomly selecting extraction forms re-entering data and comparing with the original file. Discrepancies were corrected after consultation with authorized personnel who verified the information with the SB590885 original record in each site. Extraction forms excluded were those missing age gender height weight and two or more of the following: resting blood pressure fasting glucose triglyceride and HDL. The study was approved by the Institutional Review Board of the University of Puerto Rico Universidad Central del Caribe and the Mayo Clinic in Rochester MN. Study Outcomes The most recent data available in each clinical record were used for analyses. Primary variables included: waist circumference body mass index (BMI: kg/m2) fasting glucose triglycerides and HDL use of antihypertensive and lipid control medications resting systolic and diastolic blood pressures and diagnosis of diabetes. Waist circumference was used as an index of visceral fat and BMI as an index of obesity both were collapsed into one criterion SB590885 called body shape. Other variables included: gender date of birth date and age at HIV diagnosis viral load CD4 count education alcohol consumption hepatitis C co-infection smoking and history of antiretroviral medications. The National Cholesterol Education Program – Adult Treatment Panel III (NCEP-ATPIII) criteria were used.

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