Supplementary MaterialsSupplementary Information 41467_2017_1883_MOESM1_ESM
Supplementary MaterialsSupplementary Information 41467_2017_1883_MOESM1_ESM. after X-rays. The upregulation by Ku80 depletion needs Chk1 activation following DNA end-resection by Exonuclease 1. DSBs activate STAT1 and STAT3 signalling, and IRF1 is required for DSB-dependent PD-L1 upregulation. Thus, our findings reveal the involvement of DSB repair in PD-L1 expression and provide mechanistic understanding into how PD-L1 appearance is … [Read more…]