The paraventricular nucleus of the hypothalamus (PVH) plays a central role
The paraventricular nucleus of the hypothalamus (PVH) plays a central role in regulating the hypothalamic-pituitary-adrenal (HPA) axis. treated hypothalamic cells that express CRH with the HDAC inhibitor trichostatin A (TSA). As predicted, treatment with TSA led to increased CRH mRNA levels and promoter activity. Although co-treatment with Dex (10?7 M) reduced the TSA effect on … [Read more…]