Cancer-associated mutations often result in perturbed mobile energy metabolism and deposition
Cancer-associated mutations often result in perturbed mobile energy metabolism and deposition of potentially harmful oncometabolites. for the AlkB family members enzymes. Both D- and L-2HG considerably inhibited the individual DNA fix enzymes ALKBH2 and ALKBH3 under pathologically relevant concentrations (73C88% for D-2HG and 31C58% for Nrp2 L-2HG inhibition). This function provides a brand-new perspective how … [Read more…]