ATM kinase alerts DNA dual strand breaks (DSB) to cell routine
ATM kinase alerts DNA dual strand breaks (DSB) to cell routine arrest via p53 and DNA fix. which is defective in the condition Ataxia Telangeictasia (A-T) that’s characterised by neurodegeneration, immunodeficiency, tumor pre-disposition and an intensive hypersensitivity to ionising rays (IR) and various other DSB-inducing real estate agents (2). In response to DSBs ATM initiates … [Read more…]