In forebrain neurons, Ca2+ triggers exocytosis of readily releasable vesicles by
In forebrain neurons, Ca2+ triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and gradual vesicle exocytosis, respectively. or -7 was enough to recovery the RRP size in neurons lacking both synaptotagmin-1 and -7. Although maintenance of RRP size was Ca2+-indie, mutations in Ca2+-binding sequences of synaptotagmin-1 or synaptotagmin-7which … [Read more…]