Epidermal growth factor receptor (EGFR) inhibitors such as for example gefitinib
Epidermal growth factor receptor (EGFR) inhibitors such as for example gefitinib show antitumor activity within a subset of non little cell lung (nscl) cancer individuals having mutated EGFR. xenograft phospho-Akt was inhibited by PX-866 however, not by gefitinib. A significant toxicity of PX-866 adminsitration was hyperglycemia with reduced blood sugar tolerance, that was reversed upon … [Read more…]