Supplementary MaterialsVideo S1. To visualize ERK activity in thymocytes, we here
Supplementary MaterialsVideo S1. To visualize ERK activity in thymocytes, we here developed knockin reporter mice expressing a F?rster/fluorescence resonance energy transfer (FRET)-based biosensor for ERK from your locus. Live imaging of thymocytes isolated from your reporter mice revealed that ERK regulates thymocyte motility in a subtype-specific manner. Unfavorable correlation between ERK activity and motility was … [Read more…]