Hypertensive transgenic (mRen2)27 rats with overexpression from the mRen2 gene have
Hypertensive transgenic (mRen2)27 rats with overexpression from the mRen2 gene have impaired baroreflex sensitivity (BRS) for heartrate control and high NADPH oxidase and kinase-to-phosphatase signaling activity in medullary tissue in comparison to normotensive Hannover Sprague-Dawley control rats. Tempol considerably decreased NADPH oxidase activity in human brain dorsal medullary tissues, but acquired no influence on MAP … [Read more…]