Aims During activation of cardiac myocytes, significantly less than 1% of
Aims During activation of cardiac myocytes, significantly less than 1% of cytosolic Ca can be free; the others will buffers, mainly SERCA, and troponin C. unmasking the part of troponin. This impact was verified in WT cells where SERCA activity was clogged with the use of thapsigargin. On the other hand, ISO improved Ca buffering … [Read more…]