Background Activation of metabotropic glutamate receptor 5 (mGluR5) by (RS)-2-chloro-5-hydroxyphenylglycine (CHPG)
Background Activation of metabotropic glutamate receptor 5 (mGluR5) by (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) was proven to suppress microglia activation and reduce the launch of associated pro-inflammatory mediators. BV-2 microglia with 100?M MPEP increased intracellular reactive air species (ROS), mitochondrial superoxide, mitochondrial mass aswell mainly because inducible nitric oxide synthase (iNOS) and IL-6 expression. Furthermore, MPEP decreased mobile … [Read more…]