Purpose of the review B-cell tumors originating from the transformation of
Purpose of the review B-cell tumors originating from the transformation of germinal center (GC) B-cells frequently harbor genetic mutations leading to constitutive activation of CCNB1 the nuclear factor-(encoding BLIMP1)[8 9 As a result the deregulated expression or inactivation of those genes disturbs the normal physiology of the GC-reaction by exerting pro-survival or pro-proliferative effects or … [Read more…]