Supplementary MaterialsSupplementary Information 41467_2018_6878_MOESM1_ESM. ligands, such as for example arginylated (Nt-R)
Supplementary MaterialsSupplementary Information 41467_2018_6878_MOESM1_ESM. ligands, such as for example arginylated (Nt-R) substrates. Right here, we explain the structural system for selective reputation of Nt-R from the ZZ site of p62 (p62ZZ). We display that binding of p62ZZ to Nt-R substrates stimulates p62 aggregation and macroautophagy and is necessary for autophagic targeting of p62. p62 is … [Read more…]