Although disruption of mitochondrial homeostasis and biogenesis (MB) is a widely
Although disruption of mitochondrial homeostasis and biogenesis (MB) is a widely recognized pathophysiologic feature of sepsis-induced severe kidney injury (AKI), the molecular mechanisms in charge of this phenomenon are unidentified. Immunoblot analysis uncovered activation of tumor development locus 2/mitogen-activated proteins kinase kinase/extracellular signal-regulated kinase (TPL-2/MEK/ERK) signaling in the renal cortex by LPS. Pharmacologic inhibition of … [Read more…]