Continual agonist-induced production of the next messengers InsP3 and diacylglycerol needs
Continual agonist-induced production of the next messengers InsP3 and diacylglycerol needs stable delivery of phosphatidylinositol (PtdIns) from its site of synthesis in the ER towards the plasma membrane (PM) to keep PtdIns(4,5)RdgB homolog, Nir2, a presumed PtdIns transfer protein, not merely exchanges PtdIns through the ER towards the PM but also exchanges PtdOH to the … [Read more…]