Accelerated senescence is normally an initial response to mobile strains including
Accelerated senescence is normally an initial response to mobile strains including DNA harming agents (e. we discovered that X-ray publicity resulted in hyperphosphorylation of IGF-1R, the receptor for IGF-1 and -2. Treatment with AG1024, an IGF-1R inhibitor, suppressed IR-induced upregulation of p53, p21/waf1, and SA–gal. Jointly these findings claim that IGF-1R is normally an integral … [Read more…]