From the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit
From the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac IKs current with mutations causing short and long QT cardiac arrhythmias. selectivity of KCNQ stations towards the opener retigabine and present an individual amino acidity substitution (M217W) can confer awareness to dKCNQ. We present dKCNQ has very similar electrophysiological … [Read more…]