Gain-of-function mutations in exon 3 of -catenin (exon 3 mutations, and
Gain-of-function mutations in exon 3 of -catenin (exon 3 mutations, and complete sequencing revealed gain-of-function mutations elsewhere in the gene in a few of the tumors, increasing the entire mutation rate of recurrence to 75%. -Catenin, encoded by mutations.12 But 50% of WT1-mutant Wilms tumors lacked such mutations, departing open the query of an important … [Read more…]