The Hippo pathway is an evolutionarily conserved pathway that controls cell
The Hippo pathway is an evolutionarily conserved pathway that controls cell proliferation, organ size, tissue regeneration and stem cell self-renewal. Lats2 knockdown, or expression of c-Abl mutants SC75741 supplier that escape inhibition by Lats2, enabled DNA damage-induced apoptosis of densely plated cells, while Lats2 overexpression inhibited apoptosis in sparse cells. These findings explain a long-standing … [Read more…]