Squamous cell carcinomas (SCCs) with an infiltrative invasion pattern carry an
Squamous cell carcinomas (SCCs) with an infiltrative invasion pattern carry an increased threat of treatment failure. appearance by mesenchymal-like cells was reduced in the spheroid model and in individual SCCs, we hypothesized that SCCs change toward infiltrative invasion mediated by this subpopulation during anti-EGFR therapy. Anti-EGFR treatment of spheroids using erlotinib or cetuximab improved infiltrative … [Read more…]