The main constituent of senile plaques in Alzheimers disease is a
The main constituent of senile plaques in Alzheimers disease is a 42-aa peptide, known as -amyloid (A). codons 670/671 in APP (APP Swedish) prospects to improved cleavage in the -secretase scissile relationship and improved A development. An inhibitor of vacuolar ATPases, bafilomycin, selectively inhibits the actions of -secretase in cell tradition, suggesting a requirement of … [Read more…]