Kappa-opioid agonists are particularly efficacious in the treating peripheral pain but
Kappa-opioid agonists are particularly efficacious in the treating peripheral pain but have problems with central anxious system (CNS)-mediated effects that limit their advancement. EC50 in the writhing assay was 0.032 mg/kg while no activity was detectable in the hotplate assay at dosages up to 30 mg/kg, indicating a peripheral selectivity VP-16 of 900-fold. We suggest … [Read more…]