Chronic neuroinflammation plays a significant role in the development and maintenance
Chronic neuroinflammation plays a significant role in the development and maintenance of neuropathic pain. nitric oxide synthase, in the ipsilateral vertebral dorsal horn. Furthermore, flexibilide attenuated the CCI-induced downregulation of vertebral transforming growth element-1 (TGF-1) at 2 weeks after medical procedures. Finally, i.t. SB431542, a selective inhibitor of TGF- type I receptor, clogged the analgesic … [Read more…]