The main genetic risk factor for Alzheimers disease (AD), apolipoprotein E4
The main genetic risk factor for Alzheimers disease (AD), apolipoprotein E4 (ApoE4), continues to be suggested to possess detrimental effects on neurons, including direct toxicity via apoptosis. toxicity was avoided by overexpression of Trx1 and various other endogenous Question-1 inhibitors. Our data shows that down-regulation of Trx1 can be mixed up in toxicity due to … [Read more…]