Three analogues from the dual -/-antagonist, H-Dmt-Tic-R-NH-CH2-Ph (R = 1, Lys-Z;
Three analogues from the dual -/-antagonist, H-Dmt-Tic-R-NH-CH2-Ph (R = 1, Lys-Z; 2, Lys-Ac; 3, Lys) had been analyzed in vivo: 1 and 2 exhibited fragile bioactivity, while 3 injected intracerebroventricularly was a potent dual antagonist for morphine- and deltorphin C-induced antinociception much like naltrindole (-antagonist), but 93% as effectual as naloxone (non-specific opioid receptor antagonist) … [Read more…]