Aldosterone binds towards the mineralocorticoid receptor (MR) and exerts pleiotropic results
Aldosterone binds towards the mineralocorticoid receptor (MR) and exerts pleiotropic results beyond enhancing renal sodium reabsorption. the cardiac-like cell range H9C2 utilizing a reporter gene assay and 935467-97-3 known endogenous aldosterone-regulated cardiac genes. Torasemide didn’t alter MR nuclear translocation. Aldosterone-induced MR transactivation activity was decreased from the MRA spironolactone, not really by torasemide. Spironolactone clogged … [Read more…]