The result of differential signalling by IL-6 and leukaemia inhibitory factor
The result of differential signalling by IL-6 and leukaemia inhibitory factor (LIF) which signal by gp130 homodimerisation or LIFR/gp130 heterodimerisation on survival and hypertrophy was studied in neonatal rat cardiomyocytes. and nitric oxide (Simply no) creation. IL-6, LIF and PE induced cardiomyocyte hypertrophy, but with phenotypic variations in ANF and SERCA2 manifestation and myofilament company … [Read more…]