Supplementary Components1. for Hic-5 localization to FAs. Significantly, we discovered that
Supplementary Components1. for Hic-5 localization to FAs. Significantly, we discovered that Hic-5 appearance is necessary for the TGF-mediated upsurge in FA amount, and adhesive migration and forces. Mechanistically, Nox4 downregulation impedes Smad signaling by TGF, and Hic-5 and Hsp27 upregulation by TGF is blocked in Smad4-deficient cells. Conclusions Hic-5 and Hsp27 are effectors of Nox4 … [Read more…]