We speculated whether the appearance of clonal CD4+ T cells might
We speculated whether the appearance of clonal CD4+ T cells might reflect changes in the T-cell features and T-cell subset distribution. Strikingly, we found that while T cells in the peripheral blood of CLL individuals were usually skewed towards a high CD4+/CD8+ ratio, CD4+ T cells from IgV-UM non-stereotyped CLL individuals approximately equaled the number … [Read more…]