Purpose Galeterone inhibits the enzyme CYP17A1 and happens to be in
Purpose Galeterone inhibits the enzyme CYP17A1 and happens to be in stage 2 clinical studies for castration-resistant prostate tumor (CRPC). however, not in PCa cells expressing wildtype AR. Further transfection research using steady LNCaP and Computer3 cell lines ectopically expressing wildtype or T878A mutant ARs verified that galeterone selectively enhances degradation from the T878A mutant … [Read more…]