The TGF relative Nodal continues to be implicated in heart induction
The TGF relative Nodal continues to be implicated in heart induction through misexpression of the dominant negative version of the sort I Nodal receptor (Alk4) and targeted deletion from the co-receptor Cripto in murine ESCs and mouse embryos; nevertheless, whether Nodal works straight or indirectly to induce center cells or interacts with additional signaling substances … [Read more…]