Endothelin-1 causes ETA receptor-mediated enhancement of capsaicin-induced nociception in mice. receptor
Endothelin-1 causes ETA receptor-mediated enhancement of capsaicin-induced nociception in mice. receptor agonists sarafotoxin S6c (up to 30?pmol) and IRL 1620 (up to 100?pmol) were inactive, whereas endothelin-3 (up to 30?pmol) induced just modest oedema. ETA receptor antagonists BQ-123 (1?nmol, we.pl.) or A-127722-5 (6?mol?kg?1, i.v.) PAC-1 avoided all ramifications of endothelin-1 (10?pmol), however the ETB receptor … [Read more…]