Open in another window Figure 1 Model for senescence induction in
Open in another window Figure 1 Model for senescence induction in HCC with DLC1 lossReconstitution of DLC1 and depletion of MKL1 and 2 induce cellular senescence via activation of MAPK and p16INK4a/pRb pathways (see text message for information). Oddly enough, senescence pathways could be re-engaged upon depletion of MKL1/2 or reintroduction of DLC1 (Figure ?(Figure1).1). … [Read more…]