Background Selective and reversible inhibitors of individual Cathepsin K (CatK), including
Background Selective and reversible inhibitors of individual Cathepsin K (CatK), including odanacatib (ODN), have already been designed as potential therapeutics for the treating osteoporosis. CatK as well as the rabbit bone tissue resorption assay demonstrated that three from the four substances (L-006235, L-873724, and ODN) experienced comparable potencies in the reduced amount of collagen degradation. … [Read more…]