Angiotensin II (ANG II)-induced mitogen-activated proteins kinase (MAPK) signaling upregulates angiotensin
Angiotensin II (ANG II)-induced mitogen-activated proteins kinase (MAPK) signaling upregulates angiotensin II type-1 receptors (In1R) in hypothalamic paraventricular nucleus (PVN) and plays a part in In1R-mediated sympathetic excitation in center failing. the aldosterone-induced raises in RSNA, HR, and MBP. Intracerebroventricular infusion of either the mineralocorticoid receptor antagonist RU-28318 or the AT1R antagonist losartan clogged aldosterone-induced … [Read more…]