History and Purpose The NMDA receptor can be an important target
History and Purpose The NMDA receptor can be an important target of alcohol action in the mind. Six pairs of positions in GluN1/GluN2B considerably interacted to modify ethanol inhibition: Gly638/Met824, Gly638/Leu825, Phe639/Leu825, Phe639/Gly826, Met818/Phe637 and Val820/Phe637. Tryptophan substitution at Met824 or Leu825 in GluN2B didn’t alter ethanol level of sensitivity but interacted with positions in … [Read more…]