Supplementary MaterialsSupp Fig 1. Shh is a critical mediator of this
Supplementary MaterialsSupp Fig 1. Shh is a critical mediator of this effect. Shh induces differential upregulation of the transcription factor Gli1, which mediates Shh-induced NSC differentiation. However, despite the increase in Shh and the fact that Gli1 was initially increased during early inflammation of EAE and active lesions of MS, Gli1 was significantly decreased in … [Read more…]