Although DNA nonhomologous end-joining repairs most DNA double-strand breaks (DSBs) in
Although DNA nonhomologous end-joining repairs most DNA double-strand breaks (DSBs) in G2 phase, past due repairing DSBs undergo resection and repair by homologous recombination (HR). stage, 53BP1 is necessary for HR at HC-DSBs using its function being to market phosphorylated KAP-1 foci development. BRCA1, on the other hand, is usually dispensable for pKAP-1 foci development … [Read more…]