The Erythrina alkaloids erysodine and dihydro–erythroidine (DHE) are potent and selective
The Erythrina alkaloids erysodine and dihydro–erythroidine (DHE) are potent and selective competitive inhibitors of 42 nicotinic acetylcholine receptors (nAChRs), but small is well known about the molecular determinants from the sensitivity of the receptor subtype to inhibition by this class of antagonists. nevertheless, just 4Trp182 was expected to contact destined antagonist, recommending 4Tyr230, 2Trp82, and … [Read more…]