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Targeting the ubiquitin–proteasome system for cancer therapy

BMS-754807

Background Autotaxin (ATX, NPP-2), originally purified like a potent tumor cell

December 11, 2018 by Katherine Lewis Leave a Comment

Background Autotaxin (ATX, NPP-2), originally purified like a potent tumor cell motility element, is now regarded as the long-sought plasma lysophospholipase D (LPLD). L-histidine and everything lower cell viability or adhesion. Bottom line L-histidine inhibition of LPLD isn’t a straightforward stoichiometric chelation of steel ions but can be much more likely a complicated interaction with … [Read more…]

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