Cirrhotic rats show higher expression levels of hepatic RhoA and Rho-kinase
Cirrhotic rats show higher expression levels of hepatic RhoA and Rho-kinase than normal healthy rats, and the activation of this signaling pathway leads to portal hypertension. GGPP-treated rat main hepatic stellate cells (HSCs) and a human being stellate cell collection (LX-2) was examined by stream cytometry. Intrahepatic responsiveness and level of resistance to the 1-adrenoceptor … [Read more…]