Hypoglycemia impairs blood-brain hurdle (BBB) endothelial function; a significant hallmark in
Hypoglycemia impairs blood-brain hurdle (BBB) endothelial function; a significant hallmark in the pathogenesis of varied CNS disorders. Nrf2 manifestation in hCMEC/D3 cells abrogated the manifestation of claudin-5 and VE-cadherin, while ZO-1 was up-regulated. These results were paralleled with a decrease in electric level of resistance of hCMEC/D3 monolayers and potential upsurge in permeability to all … [Read more…]